Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21
نویسندگان
چکیده
منابع مشابه
Higher incidence of death in multi-vessel coronary artery disease patients associated with polymorphisms in chromosome 9p21
BACKGROUND We investigated whether 9p21 polymorphisms are associated with cardiovascular events in a group of 611 patients enrolled in the Medical, Angioplasty or Surgery Study II (MASS II), a randomized trial comparing treatments for patients with coronary artery disease (CAD) and preserved left ventricular function. METHODS The participants of the MASS II were genotyped for 9p21 polymorphis...
متن کاملAssociation Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
Background: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. Methods: Blood samples were collected from 200 C...
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BACKGROUND Chromosome 9p21 single nucleotide polymorphisms (SNPs) have been shown to be associated with coronary heart disease in multiple studies. The aim of the present study was to identify whether these SNPs are associated with recurrent myocardial infarction (MI), revascularization, or death in acute coronary syndrome (ACS) patients or in those undergoing coronary artery bypass grafting (C...
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Background: Iron can causes lipid peroxidation in vivo and in vitro. Iron promotes myocardial injury in experimental animals. Low Density Lipoprotein (LDL) oxidation by oxidants including iron have a central role in atherosclerotic process. By this means, evaluation of serum iron in patients with coronary artery disease (CAD) has a significant importance. Materials and Methods: In this cross s...
متن کاملComparison of Treatment Outcomes in Off-pump Coronary Artery Bypass Graft and Medical Therapy in Patients with Triple-vessel Coronary Artery Disease and Severe Ventricular Dysfunction
Introduction: Heart failure is a major hazard for public health. Despite recent advance in medical therapy, there is not enough information on the outcome of off-pump coronary artery bypass (OPCAB) and medical therapy on the patients with severe ventricular dysfunction and triple-vessel (CAD). This study aimed to compare treatment outcomes and mortality rate in patients undergoing off-pump coro...
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ژورنال
عنوان ژورنال: BMC Cardiovascular Disorders
سال: 2012
ISSN: 1471-2261
DOI: 10.1186/1471-2261-12-61